• LEANDRO Z. AGUDELO † et al. Systems genomics data integration reveals a new master regulator of mitochondrial function in metabolic disease. In submission
  • LEANDRO Z. AGUDELO †, Duarte Ferreira † et al. Skeletal Muscle PGC-1α1 Reroutes Kynurenine to Support Aspartate Biosynthesis and Mitochondrial Respiration. Accepted, in press 



  • REMY TUYERAS. Category theory for genetics I: mutations and sequence alignments. Arxiv, Mathematics, 2018

  • REMY TUYERAS. Category Theory for Genetics. Arxiv, Mathematics, 2018

  • LEANDRO Z. AGUDELO, Duarte Ferreira et al. Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation. Cell Metabolism, 2018 


  • NA SUN et al. Inference of differentiation time for single cell transcriptomes using cell population reference data. Nature Communications
  • REMY TUYERAS. Elimination of quotients in various localisations of premodels into models. Arxiv, Mathematics

  • Brendan FongDavid I. Spivak, REMY TUYERAS. Backprop as Functor: A compositional perspective on supervised learning. Arxiv, Mathematics

  • Igor Cervenka, LEANDRO Z. AGUDELO, Jorge L. Ruas. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. Science, 2017
  • Malenczyk K, Girach F, Szodorai E, Storm P, SEGERSTOLPE Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T. A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover. EMBO Journal, 2017
  • Giustacchini A, Thongjuea S, Barkas N, Woll PS, Povinelli BJ, Booth CAG, Sopp P, Norfo R, Rodriguez-Meira A, Ashley N, Jamieson L, Vyas P, Anderson K, SEGERSTOLPE Å, Qian H, Olsson-Strömberg U, Mustjoki S, Sandberg R, Jacobsen SEW, Mead AJ. Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia. Nature Medicine, 2017
  • Richard Mills, Hermes Taylor-Weiner, Jorge C. Correia, LEANDRO Z. AGUDELO et al. Neurturin is a PGC-1a1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation. Molecular Metabolism, 2017



  • SEGERSTOLPE Å †, Palasantza A †, Eliasson P, Andersson EM, Andréasson AC, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Ämmälä C, Sandberg R. Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes. Cell Metabolism, 2016
  • Maja Schlittler, Michel Goiny, LEANDRO Z. AGUDELO et al. Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans. AJP, 2016 
  • Vicente Martínez-Redondo, Paulo R. Jannig et al. Peroxisome Proliferator-activated Receptor Coactivator-1 Isoforms Selectively Regulate Multiple Splicing Events on Target Genes. JBC, 2016 



  • REMY TUYERAS. Sketches in higher category theory. Thesis
  • Jorge C. Correia, Julie Massart et al. Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism. Molecular Metabolism, 2015 



  • LEANDRO Z. AGUDELO †, Teresa Femenıa † et al. Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression. Cell, 2014 



  • Lebaron S, SEGERSTOLPE Å, French SL, Dudnakova T, de Lima Alves F, Granneman S, Rappsilber J, Beyer AL, Wieslander L and Tollervey D. Rrp5 binding at multiple sites coordinates pre-rRNA processing and assembly. Molecular Cell, 2013
  • SEGERSTOLPE Å, Granneman S, Björk P, de Lima Alves F, Rappsilber J, Andersson C, Högbom M, Tollervey D and Wieslander L. Multiple RNA interactions position Mrd1 at the site of the small subunit pseudoknot within the 90S pre-ribosome. Nucleic Acids Research, 2013
  • Kallberg Y, SEGERSTOLPE Å, Lackmann F, Persson B and Wieslander L. Evolutionary conservation of the ribosomal biogenesis factor Rbm19/Mrd1: implications for function. PLoS One, 2012

(† equal contribution)